Ipamorelin

Ipamorelin is a third-generation, pentapeptide growth hormone secretagogue (GHS) that selectively targets the Ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus. It distinguishes itself from other GHSs by its remarkable specificity, stimulating a robust, physiological GH pulse while exhibiting minimal effects on acyl-ghrelin pathways, meaning it does not significantly increase hunger (orexigenic effect), cortisol, or prolactin levels. This clean profile makes it an exceptional research tool for studying the pure effects of GH pulses on lipolysis, lean muscle accrual, and connective tissue strength. Its half-life of approximately 2 hours allows for pulsed delivery models. Research often pairs Ipamorelin with CJC-1295 or Sermorelin to exploit a dual-pathway synergy (GHS + GHRH), which yields a statistically significant amplification of the GH response compared to either peptide alone.