IGF-1 LR3
$110.00
Insulin-like Growth Factor-1 Long R3 (IGF-1 LR3) is a highly potent, synthetic analogue of endogenous IGF-1, engineered with an 83-amino acid sequence that includes a 13-amino acid extension at the N-terminus (R3) and a glutamic acid substitution at position 3. This modification dramatically reduces its binding affinity to IGF-binding proteins (IGFBPs), resulting in a significantly extended biological half-life of over 12 hours compared to just minutes for native IGF-1. It exerts its anabolic effects by binding with high affinity to the IGF-1 receptor (IGF-1R), triggering the PI3K/AKT signaling cascade which leads to profound protein synthesis, hyperplasia, and suppression of apoptosis. In musculoskeletal research, it is the gold standard for studying muscle hypertrophy, satellite cell activation, and nitrogen retention. Its potent hypoglycemic effects also make it a valuable tool for studying glucose transport mechanisms. Due to its extreme potency, researchers must utilize precise micro-dosing protocols.
Insulin-like Growth Factor-1 Long R3 (IGF-1 LR3) is a highly potent, synthetic analogue of endogenous IGF-1, engineered with an 83-amino acid sequence that includes a 13-amino acid extension at the N-terminus (R3) and a glutamic acid substitution at position 3. This modification dramatically reduces its binding affinity to IGF-binding proteins (IGFBPs), resulting in a significantly extended biological half-life of over 12 hours compared to just minutes for native IGF-1. It exerts its anabolic effects by binding with high affinity to the IGF-1 receptor (IGF-1R), triggering the PI3K/AKT signaling cascade which leads to profound protein synthesis, hyperplasia, and suppression of apoptosis. In musculoskeletal research, it is the gold standard for studying muscle hypertrophy, satellite cell activation, and nitrogen retention. Its potent hypoglycemic effects also make it a valuable tool for studying glucose transport mechanisms. Due to its extreme potency, researchers must utilize precise micro-dosing protocols.
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