AHK-CU

AHK-CU (Alanine-Histidine-Lysine-Copper) is a naturally occurring, second-generation copper peptide specifically researched for its potent effects on hair follicle biology and dermal elasticity. While similar to GHK-CU, AHK-CU has a superior affinity for stimulating the proliferation of dermal papilla cells (DPCs) by upregulating the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-7 (FGF-7) in the hair cycle. It effectively downregulates the inflammatory cytokines (like TGF-β1) that are responsible for follicular miniaturization observed in androgenic alopecia (pattern baldness). Beyond hair, it stimulates the synthesis of elastin, collagen IV, and proteoglycans, making it vital for skin turgor research. Its copper-bound state ensures efficient enzymatic cofactor delivery for lysyl oxidase (an enzyme critical for cross-linking collagen and elastin). Storage requires light-proof containers to prevent copper reduction and maintain peptide stability.