5-Amino-1MQ

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a highly potent, small-molecule inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide to 1-methylnicotinamide (MNA). By selectively inhibiting NNMT, 5-Amino-1MQ prevents the depletion of the methyl donor S-adenosylmethionine (SAM) and increases intracellular levels of NAD+ via the salvage pathway. This metabolic shift activates the NAD+-dependent sirtuin pathways, promoting lipid oxidation and thermogenesis in adipocytes. Research heavily involves its application in obesity and metabolic dysfunction, showing remarkable efficacy in reducing white adipose tissue (WAT) mass and improving insulin sensitivity without affecting caloric intake. Its small molecular structure allows for exceptional oral bioavailability in research models, making it a unique alternative to injectable peptides for metabolic studies.